Insulin-based regulation of glucose-functionalized nanoparticle uptake in muscle cells
Journal
Journal of Materials Chemistry B
Journal Volume
2
Journal Issue
29
Pages
4610-4614
Date Issued
2014
Author(s)
Abstract
Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular uptake of NPs through membrane protein recognition in a specific and fine-tunable fashion. ? 2014 the Partner Organisations.
Type
journal article