Genetic Epidemiological Study on Association between Polymorphisms in Testosterone-Related Genes and Risk of Male Lung Adenocarcinoma in Taiwan
Date Issued
2006
Date
2006
Author(s)
Jan, I-Shiow
DOI
en-US
Abstract
Background: Lung cancer is the leading cause of cancer death in Taiwan. This study aimed to investigate the association of male lung adenocarcinoma and polymorphism of testosterone biosynthetic and metabolic pathway-related genes, including CYP17 and SRD5A2, and the number of CAG repeat length in the androgen receptor (AG) gene.
Methods: A total of 357 male patients with lung adenocarcinoma and 357 healthy hospital controls selected by frequency matching were recruited at 6 medical centers in Taiwan from September 2002 to August 2004. These subjects had been interviewed by questionnaires and provided blood samples for analysis. The number of CAG repeat length in the AR gene and genetic polymorphisms of cytochrome17α (CYP17) and 5α-reductase type II (SRD5A2) were determined by capillary electrophoresis and TaqMan assays. Unconditional multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each genotype.
Results: After having adjusted for age, schooling year, cigarette smoking exposure, father with lung cancer, and tuberculosis, the ORs of developing lung adenocarcinoma were 1.46 (95% CI=0.85-2.47) for CYP17 A1/A1 genotype compared with A2/A2 and A2/A1 genotype and 1.79 (95% CI=1.03-3.10) for SRD5A2 Val/Val compared with Val/Leu and Leu/Leu genotypes. For AR-CAG repeats length, there was no any association with lung adenocarcinoma.
Conclusion: Our result suggest that testosterone-related gene polymorphisms including CYP17 A1/A1 and SRD5A2 Val/Val might contribute to male lung adenocarcinoma in Taiwan.
Subjects
男性肺腺癌
基因多形性
睪固酮相關基因
流行病學研究
male lung adenocarcinoma
genetic polymorphism
testosterone-related genes
epidemiological study
Taiwan
SDGs
Type
thesis