Multiple intracranial calcifications and spinal compressions: Rare complications of type Ia pseudohypoparathyroidism
Journal
Journal of Endocrinological Investigation
Journal Volume
28
Journal Issue
9
Pages
646-650
Date Issued
2005
Author(s)
Abstract
Type Ia pseudohypoparathyroidism (PHP Ia) is an unusual inherited disease. PHP Ia often causes extraskeletal calcifications and even soft tissue ossifications. Patients may present neurologic symptoms and signs related to hypocalcemia and hyperphosphatemia. We report here a 38-yr-old woman with PHP Ia who had two uncommon neurologic complications. One was involuntary movements related to basal ganglia calcification, and the other was myelopathy owing to ossifications of the posterior longitudinal ligament and multiple herniated intervertebral disks. Aggressive body weight control and corrections of hypocalcemia, hyperphosphatemia, and elevated PTH may be important to prevent these unusual neurologic complications. Regular and careful neurologic examinations should be performed for early diagnosis and treatments of these spinal lesions. ?2005, Editrice Kurtis.
Subjects
Multiple intracranial calcifications; Ossification of the posterior longitudinal ligament; Pseudohypoparathyroidism Ia; Spinal cord compression; Spinal stenosis
SDGs
Other Subjects
adult; anamnesis; article; Babinski reflex; brain calcification; case report; Chinese; electromyography; Fahr disease; female; human; hyperphosphatemia; hypocalcemia; intervertebral disk hernia; neurologic examination; neurological complication; nuclear magnetic resonance imaging; ossification; preschool child; pseudohypoparathyroidism; pseudohypoparathyroidism ia; spinal cord compression; spinal cord disease
Type
journal article