Atypical femoral fractures shortly after osteonecrosis of the jaw in a postmenopausal woman taking alendronate for osteoporosis
Journal
Journal of Clinical Endocrinology and Metabolism
Journal Volume
98
Journal Issue
4
Pages
E723-E726
Date Issued
2013
Author(s)
Abstract
Context: Bisphosphonates effectively increase bone mineral density and reduce fracture risk in patients with osteoporosis, but there are concerns about osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFFs) in the long-term users. So far both complications have not been reported as occurring simultaneously in an osteoporotic individual on oral alendronate. Objective: The aim of this study was to report a postmenopausal woman presenting with concomitant ONJ and AFF on oral alendronate treatment. Subject, Measures, and Result: The patient wasa 63-year-old woman with a history of rheumatoid arthritis for 30 years and diabetes for 3 years. Spinal compression fractures at levels L3 and L4 were documented, and she took alendronate 70mg weekly for 7 years. Sheis the first case whose dental periapical imaging and pelvic radiography documented her ONJ and AFF, which developed subsequently within 6 months. Conclusions: This case report supports the association of both ONJ and AFF with long-term oral bisphosphonate therapy. Copyright ? 2013 by The Endocrine Society.
SDGs
Other Subjects
alendronic acid; parathyroid hormone[1-34]; adult; article; blood cell count; bone density; bone pain; case report; chronic osteomyelitis; compression fracture; computer assisted tomography; disease association; female; femur fracture; follow up; fracture fixation; fracture nonunion; gingiva bleeding; histopathology; human; human tissue; jaw osteonecrosis; leukocytosis; long term care; maxilla resection; pelvis radiography; postmenopause osteoporosis; priority journal; tooth implantation; tooth radiography; Administration, Oral; Alendronate; Bone Density Conservation Agents; Female; Femoral Fractures; Humans; Jaw Diseases; Middle Aged; Osteonecrosis; Osteoporosis, Postmenopausal
Type
journal article