Three new taxane diterpenoids from Taxus sumatrana
Journal
Journal of Natural Products
Journal Volume
68
Journal Issue
1
Pages
90-93
Date Issued
2005
Author(s)
Abstract
Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5-16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.
SDGs
Type
journal article