A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis
Journal
Angewandte Chemie - International Edition
Journal Volume
51
Journal Issue
40
Pages
10089-10093
Date Issued
2012
Author(s)
Abstract
Bubbling over: After endocytosis and intracellular trafficking to lysosomes, liposomes containing ammonium bicarbonate can be thermally triggered to generate CO2 bubbles (see scheme). These bubbles grow rapidly and collapse violently to induce transient cavitation, a process that can disrupt the lysosomal membrane and release lysosomal proteases, thus leading to cell necrosis. Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
cancer; cavitation; cell necrosis; liposomes; vesicles
SDGs
Other Subjects
Ammonium bicarbonates; cancer; Cell necrosis; Intracellular trafficking; Lysosomal membranes; Transient cavitation; vesicles; Ammonium compounds; Cavitation; Cell death; Enzyme activity; Liposomes; Molecular biology; Carbon dioxide; ammonium carbonate; carbon dioxide; carbonic acid derivative; article; cell survival; chemically induced disorder; drug delivery system; drug effect; flow cytometry; heat; human; lysosome; necrosis; pathology; tumor cell line; Carbon Dioxide; Carbonates; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Flow Cytometry; Hot Temperature; Humans; Lysosomes; Necrosis
Type
journal article