Clostridium difficile Bacteremia, Taiwan
Journal
Emerging Infectious Diseases
Journal Volume
16
Journal Issue
8
Pages
1204-1210
Date Issued
2010
Author(s)
Abstract
To determine clinical characteristics and outcome of patients with Clostridium difficile bacteremia (CDB), we identify ed 12 patients with CDB in 2 medical centers in Taiwan; all had underlying systemic diseases. Five had gastrointestinal diseases or conditions, including pseudomembranous colitis (2 patients); 4 recalled diarrhea, but only 5 had recent exposure to antimicrobial drugs. Ten available isolates were susceptible to metronidazole and vancomycin. Five isolates had C. difficile toxin A or B. Of 5 patients who died, 3 died of CDB. Of 8 patients treated with metronidazole or vancomycin, only 1 died, and all 4 patients treated with other drugs died (12.5% vs. 100%; p = 0.01). C. difficile bacteremia, although uncommon, is thus associated with substantial illness and death rates.
SDGs
Other Subjects
cefepime; cefmetazole; ceftriaxone; clindamycin; daptomycin; doripenem; ertapenem; fusidic acid; imipenem; meropenem; metronidazole; penicillin G; piperacillin plus tazobactam; RNA 16S; sultamicillin; teicoplanin; tigecycline; vancomycin; adolescent; adult; aged; antibiotic sensitivity; article; bacterium identification; bacterium isolate; blood culture; child; clinical article; Clostridium difficile infection; controlled study; female; genotype; human; male; minimum inhibitory concentration; nonhuman; nucleotide sequence; polymerase chain reaction; pulsed field gel electrophoresis; retrospective study; school child; sequence analysis; Taiwan; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Child; Clostridium difficile; Enterocolitis, Pseudomembranous; Female; Humans; Male; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; Taiwan; Vancomycin; Young Adult
Type
journal article