Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment
Journal
Nanoscale Horizons
Journal Volume
7
Journal Issue
4
Pages
352-367
Date Issued
2022
Author(s)
Abstract
Recent studies have found that exosomes or extracellular vehicles (EVs) are associated with cancer metastasis, disease progression, diagnosis, and treatment, leading to a rapidly emerging area of exocrine vesicle research. Relying on the superior targeting function and bio-compatibility of exosomes, researchers have been able to deliver drugs to cancer stem cells deep within tumors in mouse models. Despite significant efforts made in this relatively new field of exosome research, progress has been held back by challenges such as inefficient separation methods, difficulties in characterization/tracking, and a lack of specific biomarkers. Therefore, current researches are devoted to combining nanomaterials with exosomes to improve these shortcomings. Adding inorganic/organic nanoparticles such as artificial liposomes and iron oxide can bring more drug options and various fluorescent or magnetic diagnostic possibilities to the exosome system. Moreover, the applications of exosomes need to be further evaluated under actual physiological conditions. This review article highlights the potential of exosome-biomimetic nanoparticles for their use as drug carriers to improve the efficacy of anticancer therapy. © 2022 The Royal Society of Chemistry
SDGs
Other Subjects
Biomimetics; Diagnosis; Diseases; Liposomes; Stem cells; Targeted drug delivery; Bio-compatibility; Cancer metastasis; Disease diagnosis; Disease progression; Disease treatment; Exosomes; Extracellular; Hybrid inorganic-organic; Metastasis disease; Organic nanoparticles; Iron oxides; drug carrier; nanoparticle; animal; drug delivery system; exosome; mouse; neoplasm; Animals; Drug Carriers; Drug Delivery Systems; Exosomes; Mice; Nanoparticles; Neoplasms
Type
review