Toxicogenomics of A375 human malignant melanoma cells
Resource
Pharmacogenomics 8 (8): 1017-1036
Journal
Pharmacogenomics
Pages
1017-1036
Date Issued
2007
Date
2007
Author(s)
Cheng, Sun-Long
Liu, Rosa Huang
Sheu, Jin-Nan
Chen, Shui-Tein
Sinchaikul, Supachok
Tsay, Gregory Jiazer
Abstract
Toxicogenomics applications are increasingly applied to the evaluation of preclinical drug safety, and to explain toxicities associated with compounds at the mechanism level. In this review, we aim to describe the application of toxicogenomics tools for studying the genotoxic effect of active compounds on the gene-expression profile of A375 human malignant melanoma cells, through the other molecular functions of target genes, regulatory pathways and mechanisms of malignant melanomas. It also includes the current systems biology approaches, which are very useful for analyzing the biological system and understanding the entire mechanisms of malignant melanomas. We believe that this review would be very potent and useful for studying the toxicogenomics of A375 melanoma cells, and for further diagnostic and therapeutic applications. ? 2007 Future Medicine Ltd.
Subjects
A375 cells; Gene expression; Genotoxic effect; Microarray; Toxicogenomics
SDGs
Other Subjects
2 (3,5 di tert butyl 4 hydroxyphenyl) 1,1 ethanebisphosphonic acid tetraisopropyl ester; antineoplastic agent; ascorbic acid; bortezomib; camptothecin; ccd 779; endothelin 1; epicatechin; epigallocatechin gallate; erianin; evodiamine; fumaric acid dimethyl ester; ginsenoside Rh 2; heparin; monoclonal antibody lm 609; n (2 aminophenyl) 4 (3 pyridinylmethoxycarbonylaminomethyl)benzamide; oblimersen; pd 032591; resveratrol; sorafenib; thalidomide; unclassified drug; antineoplastic activity; bioinformatics; cancer cell culture; cancer growth; cell cycle arrest; correlation analysis; DNA microarray; drug cytotoxicity; drug research; drug safety; gene expression profiling; gene expression regulation; gene targeting; genetic database; genome analysis; genomics; genotoxicity; human; matrix assisted laser desorption ionization time of flight mass spectrometry; melanogenesis; melanoma; mitosis inhibition; nonhuman; proteomics; quantitative analysis; review; RNA interference; signal transduction; skin carcinogenesis; systems biology; toxicogenomics; Animals; Cell Line, Tumor; Gene Expression Profiling; Humans; Melanoma; Toxicogenetics
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