糖尿病對頸動脈構造及功能之影響
Date Issued
2002
Date
2002
Author(s)
蘇大成
DOI
902320B002178
Abstract
Backgrounds ：With the current trend of
aging population in Taiwan, it is urgent to
pay more attention to early detection of
atherosclerosis to prevent the atherosclerotic
diseases. Diabetes mellitus (DM) is one of
the well- known and major risk factors for
coronary and carotid arteries atherosclerosis.
Material and Methods ： One hundred and
eight DM patients and 135 non-DM control
subjects from the Chin-Shan Community
Cardiovascular Cohort participated in this
study in 2001. The carotid atherosclerosis
was measured by high-resolution B-mode
ultrasonography and expressed as maximal
intima-media thickness of the common
carotid artery (CA), internal CA, carotid bulb, and extracranial CA plaque score. The
carotid arterial compliance was measured
using common CA diameter changes, and
was defined as Distensibility Coefficient
(DC)= (2(systolic diameter - diastolic
diameter)/ systolic diameter)/(systolic
BP-diastolic BP). Results of measurements
of carotid atherosclerosis showed no
significant difference between DM and
control. However, DC decreased in DM
group while comparing with control.
Further analysis using multivariate lineal
regression model revealed that DM, age,
blood pressure components (SBP, DBP,
MAP, and PP) are important determinants of
DC. Conclusions ： Patients with DM
decreased carotid arterial distensibility
though no significant difference in carotid
atherosclerosis. Our findings support that
DM is important in the pathogenesis of
atherosclerosis in middle-aged population.
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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