Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc
Journal
International journal of biological macromolecules
Journal Volume
135
Pages
29
Date Issued
2019-08-15
Author(s)
Liang, Pi-Hui
Wang, Damao
Xing, Xiaohui
Cheng, Ting-Jen Rachel
Bulone, Vincent
Park, Jeong Hill
Hsieh, Yves S Y
Abstract
Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extraction of these polysaccharides has proved problematic and their exact composition remains unknown. Here we have analysed the composition, structure and biological activity of polysaccharides from ginseng root, stem and leaf marc fractionated using a chelator and alkali solutions. The pectic fraction has been extracted from root marc in high abundance and can activate the production of interleukine-1α and the hematopoietic growth factor by RAW 264.7 murine macrophage cells, which are important immune regulators of T-cells during inflammatory responses and infection processes. Our study reveals the potential to increase the value of ginseng marc by generating carbohydrate-based products with a higher value than animal feed.
Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extraction of these polysaccharides has proved problematic and their exact composition remains unknown. Here we have analysed the composition, structure and biological activity of polysaccharides from ginseng root, stem and leaf marc fractionated using a chelator and alkali solutions. The pectic fraction has been extracted from root marc in high abundance and can activate the production of interleukine-1α and the hematopoietic growth factor by RAW 264.7 murine macrophage cells, which are important immune regulators of T-cells during inflammatory responses and infection processes. Our study reveals the potential to increase the value of ginseng marc by generating carbohydrate-based products with a higher value than animal feed. © 2019
Subjects
Cell wall polysaccharides; Ginseng marc; Murine macrophage cells; Panax ginseng; Structure
SDGs
Other Subjects
arabinogalactan; granulocyte colony stimulating factor; hemopoietic growth factor; interleukin 1alpha; polysaccharide; immunologic factor; plant extract; polysaccharide; animal cell; Article; cell wall; chemical composition; controlled study; cytokine production; drug isolation; drug structure; ginseng; immunomodulation; mouse; nonhuman; plant leaf; plant root; plant stem; RAW 264.7 cell line; T lymphocyte; animal; chemistry; hydrolysis; isolation and purification; liquid liquid extraction; Panax; spectroscopy; structure activity relation; Animals; Cell Wall; Hydrolysis; Immunologic Factors; Liquid-Liquid Extraction; Mice; Panax; Plant Extracts; Polysaccharides; RAW 264.7 Cells; Spectrum Analysis; Structure-Activity Relationship
Publisher
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