Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C
Journal
Journal of Hepatology
Journal Volume
43
Journal Issue
2
Pages
235-242
Date Issued
2005
Author(s)
Huang W.-L.
Lai M.-Y.
Abstract
Background/Aims: Adiponectin induces insulin sensitivity and modulates inflammatory responses. We thus studied the implications of adiponectin in patients with chronic hepatitis C virus (HCV) infection inherently linked to insulin resistance. Methods: We analyzed the association of serum adiponectin levels with clinical, virologic, and histologic findings in 95 na?ve Taiwanese patients with chronic hepatitis C before and after antiviral therapy. Results: At baseline, 14 (15%) of the 95 patients were obese and 26 (27%) had type 2 diabetes mellitus. Fifty-seven patients were infected with HCV genotype 1 and 38 with genotype 2. Steatosis and periportal fibrosis was present in 44 (46%) and 69 (73%), respectively. In multivariate analysis, male gender, insulin resistance, high HCV load and genotype 2 were significantly associated with a lower serum adiponectin level. In contrast, intrahepatic gene expression of adiponectin receptors was higher in genotype 2 compared with genotype 1. Serum adiponectin level did not correlate with other clinical or histologic parameters. After treatment, change of steatosis also did not correlate with the change of adiponectin level (P=0.61). Conclusions: Adiponectin correlated with hepatitis C viral factors at both serum and liver tissue levels. The interactions among adiponectin, insulin resistance and chronic HCV infection merit further studies. ? 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
SDGs
Other Subjects
adiponectin; adult; article; chronic hepatitis; controlled study; correlation analysis; fatty liver; female; gene expression; genotype; hepatitis C; histopathology; human; human tissue; insulin resistance; liver fibrosis; major clinical study; male; non insulin dependent diabetes mellitus; obesity; priority journal; protein blood level; sex difference; virus load
Publisher
Elsevier
Type
journal article