Risk of Liver Cirrhosis Associated with Genotypes and Mutants of HBV
Date Issued
2007
Date
2007
Author(s)
Chen, Yu-Ling
DOI
en-US
Abstract
Objective
Although HBV DNA level has been shown to be an independent risk predictor for liver cirrhosis, the roles of HBV genotype and mutants in the progression of liver cirrhosis remain unclear. The aim of this study was to investigate the risk of cirrhosis associated with genotype, precore stop codon G1896A mutation and A1762T/G1764A double mutation in the basal core promoter (BCP) of hepatitis B virus (HBV).
Methods
A cohort of 2,692 untreated participants (aged 30–65), who were HBsAg(+) and anti-HCV-seronegative, was enrolled from seven townships in Taiwan between 1991 and 1992. Serum samples at cohort entry were tested for HBV viral load and genotype. A sub-cohort of 1,477 participants with HBV DNA levels ≥ 104 copies/mL was further tested for HBV mutants of G1896A and A1762T/G1764A. Newly developed liver cirrhosis cases were diagnosed by ultrasonography.
Results
Up to June 30, 2004, 305 newly diagnosed cirrhosis cases had occurred during 30,939 person-years of follow-up, with a mean follow-up time of 11.5 years. The incidence rates per 100,000 person-years for participants infected with HBV genotype B and C were 768.2 and 1,585.3, respectively. For participants infected with wild and mutant type HBV precore stop codon 1896, rates were 1,985.7 and 881.0, respectively; and for participants infected with wild and typical mutant type HBV BCP 1762/1764, rates were 912.6 and 2,210.2, respectively. After adjustment for gender, age, cigarette smoking, alcohol consumption, HBeAg status, ALT level, and HBV viral load, the hazard ratio (95% confidence interval) of liver cirrhosis was 1.7 (1.4–2.2) for genotype C compared with genotype B, 0.6 (0.4–0.9) for G1896A mutant compared with wild type, and 1.9 (1.4–2.5) for A1762T/G1764A mutant compared with wild type.
Conclusion
HBV genotype C and A1762T/G1764A mutants were risk factors for liver cirrhosis, while the emergence of G1896A mutant seemed to have a protective effect on the progression of liver cirrhosis.
Subjects
B 型肝炎病毒
肝硬化
B型肝炎病毒基因型
B型肝炎病毒突變株
Precore
Basal Core Promoter
Hepatitis B Virus
Liver Cirrhosis
HBV Genotype
HBV Mutants
SDGs
Type
thesis
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