Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
Journal
Journal of biomedical science
Journal Volume
27
Journal Issue
1
Pages
48
Date Issued
2020-04-02
Author(s)
Abstract
With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous group of non-coding transcripts longer than 200 nucleotides. Emerging evidence suggests that lncRNAs are functional and contribute to the complex regulatory networks involved in cardiovascular development and diseases. In this article, we will review recent evidence on the roles of lncRNAs in the biological processes of cardiovascular development and disorders. The potential applications of lncRNAs as biomarkers and targets for therapeutics are also discussed.
Subjects
Cardiovascular; Development; Disease; Long noncoding RNA
SDGs
Other Subjects
beta secretase 1; gap junction protein; long untranslated RNA; myocardin; polycomb repressive complex 2; sarcoplasmic reticulum calcium transporting adenosine triphosphatase; biological marker; long untranslated RNA; arrhythmogenesis; atherosclerosis; cardiomyopathy; cardiovascular disease; coronary artery disease; end stage renal disease; endothelium cell; heart arrhythmia; heart development; heart failure; heart infarction; heart muscle fibrosis; heart ventricle hypertrophy; heart ventricle remodeling; high throughput sequencing; human; human genome; lipid metabolism; myocardial ischemia reperfusion injury; nonhuman; priority journal; prognosis; Review; RNA sequencing; tissue regeneration; vascular smooth muscle cell; animal; cardiovascular disease; gene expression profiling; genetics; metabolism; mouse; rat; Animals; Biomarkers; Cardiovascular Diseases; Gene Expression Profiling; Humans; Mice; Rats; RNA, Long Noncoding
Publisher
BMC
Type
review