Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection
Journal
Pediatric Research
Journal Volume
79
Journal Issue
2
Pages
271-277
Date Issued
2016
Author(s)
Abstract
Background: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI. Methods: We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010-2012 in a tertiary care center. We analyzed IgM+ CD27+ memory B-cell percentages. Patients with simple and complex CHD served as controls. Results: The mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7, P < 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI (P = 0.028). Conclusion: The memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. ? 2016 International Pediatric Research Foundation, Inc.
SDGs
Other Subjects
CD19 antigen; CD22 antigen; CD27 antigen; immunoglobulin M; immunoglobulin M; Article; bacterial infection; brain abscess; child; clinical article; controlled study; disease severity; female; flow cytometry; follow up; genetic susceptibility; heterotaxy syndrome; human; male; memory cell; oxygen saturation; peripheral blood mononuclear cell; pneumococcal meningitis; preschool child; priority journal; school child; adolescent; B lymphocyte; Bacterial Infections; case control study; complication; heterotaxy syndrome; immunocompromised patient; immunological memory; immunology; immunophenotyping; infant; lymphocyte count; microbiology; Opportunistic Infections; phenotype; procedures; risk assessment; risk factor; severity of illness index; tertiary care center; Adolescent; B-Lymphocytes; Bacterial Infections; Case-Control Studies; Child; Child, Preschool; Female; Flow Cytometry; Heterotaxy Syndrome; Humans; Immunocompromised Host; Immunoglobulin M; Immunologic Memory; Immunophenotyping; Infant; Lymphocyte Count; Male; Opportunistic Infections; Phenotype; Risk Assessment; Risk Factors; Severity of Illness Index; Tertiary Care Centers
Publisher
Nature Publishing Group
Type
journal article