Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes
Journal
Clinical Epigenetics
Journal Volume
15
Journal Issue
1
Date Issued
2023-06-03
Author(s)
Chang, Xue-Yong
Abstract
Smoking can lead to the deterioration of lung function and susceptibility to diabetes. Recently, smoking was found to induce DNA methylation (DNAm) changes in some cytosine-phosphate-guanine sites (CpGs). As linear combinations of DNAm levels of aging-related CpGs, five measures of epigenetic age acceleration (EAA) have received extensive attention: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE. It is of interest to explore whether some measures of EAA can mediate the associations of smoking with diabetes-related outcomes and indices of ventilatory lung function.
Subjects
Aging; Chronological age; DNA methylation; Epigenetic clock; Methylation clock
SDGs
Publisher
BioMed Central Ltd
Type
journal article