Terpenoid-Related Metabolites from a Formosan Soft Coral Nephthea chabrolii
Resource
CHEMICAL & PHARMACEUTICAL BULLETIN 55 (4): 594
Journal
Chemical and Pharmaceutical Bulletin
Journal Volume
55
Journal Issue
4
Pages
594-597
Date Issued
2007
Date
2007
Author(s)
Su, Jui-Hsin
Abstract
Two new sesquiterpenoidal natural products chabrolidiones A and B (1 and 2), two C18 terpenoid-related carboxylic acids, ketochabrolic acid (3) and isoketochabrolic acid (4), and one naphthoquinone derivative chabrolonaphthoquinone C (5), along with two known compounds (+)-aristolone (6) and teuhetenone A (7) were isolated from a Formosan soft coral Nephthea chabrolii. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of related metabolites. Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described. ? 2007 Pharmaceutical Society of Japan.
Subjects
Nephthea chabrolii; Sesquiterpenoidal natural product; Soft coral
SDGs
Other Subjects
1,4 naphthoquinone derivative; aristolone; chabrolidione a; chabrolidione b; chabrolonaphthoquinone c; drug metabolite; isoketochabrolic acid; ketochabrolic acid; natural product; terpenoid; teuhetenone a; unclassified drug; article; cancer cell; carbon nuclear magnetic resonance; coral; cytotoxicity; drug isolation; drug structure; drug synthesis; human; IC 50; Nephthea chabrolii; nuclear magnetic resonance; nuclear Overhauser effect; proton nuclear magnetic resonance; Animals; Anthozoa; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Terpenes
Type
journal article
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