Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients
Journal
Clinical proteomics
Journal Volume
20
Journal Issue
1
Pages
Article number 17
Date Issued
2023-04-08
Author(s)
Chen, Zhuo Zhen
Johnson, Lloyd
Trahtemberg, Uriel
Baker, Andrew
Huq, Saaimatul
Dufresne, Jaimie
Bowden, Peter
Miao, Ming
Dos Santos, Claudia C
Marshall, John G
Abstract
Proteomic analysis of human plasma by LC-ESI-MS/MS has discovered a limited number of new cellular protein biomarkers that may be confirmed by independent biochemical methods. Analysis of COVID-19 plasma has indicated the re-purposing of known biomarkers that might be used as prognostic markers of COVID-19 infection. However, multiple molecular approaches have previously indicated that the SARS-COV2 infection cycle is linked to the biology of mitochondria and that the response to infections may involve the action of heme containing oxidative enzymes.
Subjects
ELECTROSPRAY-IONIZATION; LIQUID-CHROMATOGRAPHY; PROTEINS; TANDEM; LUCIGENIN; DNA; IDENTIFICATION; PEPTIDES; ENZYME
SDGs
Publisher
BMC
Type
journal article