The Immune Regulatory Role of Interleukin-10 In Murine Lupus
Date Issued
2007
Date
2007
Author(s)
Liu, Yu-Han
DOI
en-US
Abstract
The immunosuppressive cytokine, interleukin-10, can inhibit the activation and effector functions of T cells. It also plays a key role in differentiation and function of a regulatory T cell subset. The role that IL-10 plays in the pathogenesis of many autoimmune diseases is striking, including systemic lupus erythematosus. Delivery of IL-10 cytokine alone in the inflammatory region to alleviate the severity of this disease, or enhance the function of regulatory T cells induced by the cytokine is the principle of tissue-specific cytokine treatment. In this study, we focused on the immune-modulatory effect of IL-10 in the activation of T cells. Decreased production of IL-2 was observed in different T cell lines when cultured with IL-10. To further study the inhibitory mechanisms of IL-10 on T cells, we examined the signaling pathways downstream of IL-10 and found the increased PPARγ expression was induced by IL-10 treatment. In addition, the inhibition of IL-2 secretion by IL-10 could be partially restored by PPARγ antagonist, GW9662. Our results suggest the inhibitory effect on T cells by interleukin-10 is partly through their downstream PPARγ. This molecule and its associated signal pathways should be taken into consideration for its potential of being new target in the development of immunotherapy against SLE. To further understand the effects of IL-10 on the disease development of SLE in vivo, we intraperitoneally injected PSG to NZB/W F1 mice to induce IL-10 production. After treatment, the mice have higher percentage of Treg population, lower glomerulonephritis, and greater survival tendencies. This suggests the potential role of IL-10 in the treatment of murine lupus.
Subjects
介白質-10
全身性紅斑性狼瘡
T細胞
自體免疫
過氧化小體增殖物活化受體
靈芝多醣體
Interleukin-10
Systemic lupus erythematosus
T cell
Autoimmune
Peroxisome proliferator-activated receptor(PPAR-gamma)
The polysaccharide components of Gernderma lucidum(PSG)
Type
other
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