Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study
Journal
Head and Neck
Journal Volume
35
Journal Issue
12
Pages
1787-1795
Date Issued
2013
Author(s)
Abstract
Background: Studies concerning prognostic factors specific for alendronate-related osteonecrosis of the jaws (ONJ) are rare. Methods We surveyed a cohort of 100 osteoporotic patients with 111 alendronate-related ONJ lesions treated during a 4-year period. Prognostic values of clinical variables and serum markers of bone turnover were assessed by univariate and multivariate analyses. Results: The cumulative complete response rate at 6 months was 48.65%. Serum bone-specific alkaline phosphatase (BSAP) level >10 μg/L, lesion depth ≦ 10 mm, and lesions in anterior regions denoted a better chance of healing within 6 months and the adjusted hazard ratios were 2.48 (95% confidence interval [CI], 1.41-4.37), 2.71 (95% CI, 1.57-4.70), and 3.94 (95% CI, 1.87-8.30), respectively. Conclusions: Early discovery of lesions and prevention of their deeper extension are crucial for improving the prognosis of alendronate-related ONJ. A higher pretreatment level of BSAP indicates a better prognosis. ? 2013 Wiley Periodicals, Inc.
SDGs
Other Subjects
alendronic acid; alkaline phosphatase; amoxicillin; amoxicillin plus clavulanic acid; chlorhexidine; clindamycin; aged; article; bone turnover; cohort analysis; female; health survey; human; jaw osteonecrosis; major clinical study; male; priority journal; prognosis; treatment response; alendronate; BSAP; CTX; ONJ; osteoporosis; Adult; Aged; Aged, 80 and over; Alendronate; Alkaline Phosphatase; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biological Markers; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Remodeling; Chlorhexidine; Clindamycin; Cohort Studies; Collagen Type I; Debridement; Female; Humans; Male; Middle Aged; Mouthwashes; Multivariate Analysis; Osteoporosis; Peptides; Prognosis; Retrospective Studies
Type
journal article