Plasma biomarkers differentiate Parkinson's disease from atypical parkinsonism syndromes
Journal
Frontiers in Aging Neuroscience
Journal Volume
10
Journal Issue
APR
Pages
123
Date Issued
2018
Author(s)
Abstract
Objective: Parkinson's disease (PD) has significant clinical overlaps with atypical parkinsonism syndromes (APS), which have a poorer treatment response and a more aggressive course than PD. We aimed to identify plasma biomarkers to differentiate PD from APS. Methods: Plasma samples (n = 204) were obtained from healthy controls and from patients with PD, dementia with Lewy bodies (DLB), multiple system atrophy, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), or frontotemporal dementia (FTD) with parkinsonism (FTD-P) or without parkinsonism. We measured plasma levels of α-synuclein, total tau, p-Tau181, and amyloid beta 42 (Aβ42) by immunomagnetic reduction-based immunoassay. Results: Plasma α-synuclein level was significantly increased in patients with PD and APS when compared with controls and FTD without parkinsonism (p < 0.01). Total tau and p-Tau181 were significantly increased in all disease groups compared to controls, especially in patients with FTD (p < 0.01). A multivariate and receiver operating characteristic curve analysis revealed that a cut-offvalue for Aβ42 multiplied by p-Tau181 for discriminating patients with FTD from patients with PD and APS was 92.66 (pg/ml)2, with an area under the curve (AUC) of 0.932. An α-synuclein cut-offof 0.1977 pg/ml could separate FTD-P from FTD without parkinsonism (AUC 0.947). In patients with predominant parkinsonism, an α-synuclein cut-offof 1.388 pg/ml differentiated patients with PD from those with APS (AUC 0.87). Conclusion: Our results suggest that integrated plasma biomarkers improve the differential diagnosis of PD from APS (PSP, CBD, DLB, and FTD-P). ? 2018 Lin, Yang, Horng, Yang, Chieh, Chen, Liu and Chiu.
Other Subjects
alpha synuclein; amyloid beta 42; amyloid beta protein; biological marker; tau protein; tau protein 181; unclassified drug; adult; area under the curve; Article; blood sampling; controlled study; corticobasal degeneration; diagnostic accuracy; differential diagnosis; diffuse Lewy body disease; disease course; disease duration; female; frontotemporal dementia; human; immunoassay; immunomagnetic separation; major clinical study; male; Parkinson disease; parkinsonism; progressive supranuclear palsy; protein phosphorylation; receiver operating characteristic; Shy Drager syndrome; treatment response
Publisher
Frontiers Media S.A.
Type
journal article