Pro- and anti-angiogenesis effects of resveratrol
Journal
In Vivo
Journal Volume
21
Journal Issue
2
Pages
365-370
Date Issued
2007
Author(s)
Chen Y.
Abstract
Resveratrol, a natural polyphenol, has a variety of effects including protection against ischemia-reperfusion injury, and antitumor and chemopreventive action against malignant tumors. In recent years, resveratrol has been found to exert pro- and anti-angiogenic effects, depending on the situation. For example, pro-angiogenic effects are noted in the peri-infarct myocardium, whereas resveratrol inhibits angiogenesis in tumors. In this article, a review of the literature concerning both pro-angiogenic and anti-angiogenic effects of resveratrol and the underlying mechanisms of its effects on angiogenesis is presented.
Subjects
Angiogenesis; Anti-angiogenesis; Pro-Angiogenesis; Resveratrol; Review
SDGs
Other Subjects
drug metabolite; resveratrol; angiogenesis inhibitor; angiogenic factor; plant extract; resveratrol; stilbene derivative; angiogenesis; antiangiogenic activity; antineoplastic activity; apoptosis; brain ischemia; cancer inhibition; cerebrovascular accident; chemoprophylaxis; drug blood level; drug distribution; drug dose comparison; drug half life; drug metabolism; drug penetration; drug potency; glioma; heart arrhythmia; heart infarction; heart protection; human; ischemia; kidney ischemia; Lewis carcinoma; low drug dose; neuroprotection; nonhuman; ovary cancer; renal protection; reperfusion injury; review; spinal cord ischemia; animal; animal model; chemistry; grape; isolation and purification; mulberry; reperfusion injury; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Humans; Models, Animal; Morus; Plant Extracts; Reperfusion Injury; Stilbenes; Vitis
Type
review