Rasburicase for huge hepatocellular carcinoma with tumor lysis syndrome: Case report
Journal
Medical Principles and Practice
Journal Volume
21
Journal Issue
5
Pages
498-500
Date Issued
2012
Author(s)
Abstract
Objective: To report a case of huge hepatocellular carcinoma associated with tumor lysis syndrome and its management. Clinical Presentation and Intervention: A 51-year-old hepatitis B carrier visited our clinic with progressive weight loss over recent months. Abdominal ultrasonography and magnetic resonance imaging revealed a huge hepatic mass in a cirrhotic liver, identified as hepatocellular carcinoma. A hepatologist and surgeon recommended transarterial chemoembolization followed by hepatectomy. The patient underwent the procedure, with the complication of tumor lysis syndrome. He was treated with a single high dose (9 mg) of rasburicase and his clinical condition improved dramatically, with acute kidney injury subsiding without emergent hemodialysis. Conclusions: This was a case of hepatocellular carcinoma with tumor lysis syndrome and acute kidney injury, treated successfully with rasburicase. Copyright ? 2012 S. Karger AG, Basel.
SDGs
Other Subjects
rasburicase; abdominal pain; acute kidney failure; adult; article; case report; chemoembolization; drug megadose; echography; fever; hepatitis B; human; liver cell carcinoma; liver cirrhosis; liver resection; liver tumor; male; nuclear magnetic resonance imaging; oliguria; single drug dose; tumor lysis syndrome; urine volume; Carcinoma, Hepatocellular; Gout Suppressants; Humans; Liver Neoplasms; Male; Middle Aged; Tumor Lysis Syndrome; Urate Oxidase
Type
journal article