Intrapleural minocycline pleurodesis for bilateral pneumothorax due to septic pulmonary embolism: a case report.
Journal
Journal of thoracic disease
Series/Report No.
Journal of Thoracic Disease
Journal Volume
16
Journal Issue
5
Start Page
3493-3502
ISSN
2072-1439
Date Issued
2024-05-31
Author(s)
Yanagiya, Masahiro
Kazama, Yoshihiro
Lal, Amos
Russo, Debora
Watanabe, Satoshi
Wada, Ami
Furuhata, Yoshiaki
Nakajima, Jun
DOI
10.21037/jtd-23-1923
Abstract
Background: Pneumothorax is a rare but serious complication of septic pulmonary embolism (SPE). SPE is a life-threatening disorder wherein infected thrombi bring infarction of the terminal and small caliber parts of the pulmonary vasculature and develop multiple nodular and cavitary lesions. Interventions other than conservative chest tube drainage for pneumothorax due to SPE have rarely been reported. Here, we present a case of bilateral pneumothorax due to SPE treated with intrapleural minocycline pleurodesis.
Case description: A 72-year-old male patient previously diagnosed as esophageal carcinoma developed metachronous bilateral pneumothorax while treated for brain metastases. Based on blood cultures and chest computed tomography images, he was diagnosed with pneumothorax secondary to SPE due to methicillin-susceptible Staphylococcus aureus bacteremia. Bilateral chest tube drainage was instituted. Continuous air leakage was found bilaterally after chest tube placement. He was treated with broad-spectrum antibiotics based on the susceptibility profile and supportive treatment for sepsis. Approximately 3 weeks later, air leakage significantly reduced. We performed intrapleural minocycline pleurodesis bilaterally to prevent the recurrence of pneumothorax; the left side was firstly treated and the right side was treated 2 weeks later. Both chest tubes were successfully removed two days after procedures. Although the patient finally died of brain metastases 1 month after pleurodesis, he never recurred pneumothorax.
Conclusions: Intrapleural minocycline pleurodesis may be one of the useful and efficacious options in terms of treating intractable pneumothorax associated with SPE. Intrapleural minocycline pleurodesis could be a consideration for intractable pneumothorax related to SPE.
Subjects
Minocycline
case report
pleurodesis
pneumothorax
septic pulmonary embolism (SPE)
Publisher
AME Publishing Company
Type
journal article