Effect of the directional blood flow on thermal dose distribution during thermal therapy: An application of a green's function based on the porous model
Journal
Physics in Medicine and Biology
Journal Volume
48
Journal Issue
11
Pages
1577-1589
Date Issued
2003
Author(s)
Abstract
This study presents the effects of directional blood flow and heating schemes on the distributions of temperature and thermal dose during thermal therapy. In this study, a transient bioheat transfer equation based on the porous medium property is proposed to encompass the directional effect of blood flow. A Green's function is used to obtain the temperature distribution for this modified bioheat transfer equation, and the thermal dose equivalence is used to evaluate the heating results for a set of given parameters. A 10 × 10 × 10 mm3 tumour tissue is heated by different heating schemes to investigate the thermal dose variation with the clinical therapeutic arrangement. For a rapid heating scheme, the domain of thermal lesion can effectively cover the desired therapeutic region. However, this domain of thermal lesion may extend to the downstream normal tissue if the porosity is high and the averaged blood velocity has a larger value.
SDGs
Other Subjects
Blood; Flow of fluids; Green's function; Porosity; Thermal effects; Thermal dose distribution; Medicine; article; biomedical engineering; blood flow; geometry; heat transfer; hyperthermic therapy; porosity; priority journal; Blood Flow Velocity; Dose-Response Relationship, Radiation; Heat; Humans; Hyperthermia, Induced; Models, Biological; Neoplasms; Neovascularization, Pathologic; Porosity; Radiation Dosage; Temperature; Therapy, Computer-Assisted
Type
journal article