All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A
Journal
Biochemical and Biophysical Research Communications
Journal Volume
477
Journal Issue
4
Pages
874-880
Date Issued
2016
Author(s)
Abstract
Patients with type 1 diabetes mellitus are associated with impairment in vitamin A metabolism. This study evaluated whether treatment with retinoic acid, the biologically active metabolite of vitamin A, can ameliorate diabetes. All-trans retinoic acid (atRA) was used to treat streptozotocin (STZ)-induced diabetic mice which revealed atRA administration ameliorated blood glucose levels of diabetic mice. This hyperglycemic amelioration was accompanied by an increase in the amount of β cells co-expressed Pdx1 and insulin and by restoration of the vascular laminin expression. The atRA-induced production of vascular endothelial growth factor-A from the pancreatic islets was possibly the key factor that mediated the restoration of islet vascularity and recovery of β?cell mass. Furthermore, the combination of islet transplantation and atRA administration significantly rescued hyperglycemia in diabetic mice. These findings suggest that vitamin A derivatives can potentially be used as a supplementary treatment to improve diabetes management and glycemic control. ? 2016 Elsevier Inc.
Subjects
All-trans retinoic acid; Islet vascularization; Type 1 diabetes mellitus; Vascular endothelial growth factor
SDGs
Other Subjects
CD31 antigen; glucose; insulin; laminin; retinoic acid; retinol derivative; streptozocin; transcription factor PDX 1; vasculotropin A; antidiabetic agent; glucose blood level; insulin; retinoic acid; vascular endothelial growth factor A, mouse; vasculotropin A; animal cell; animal experiment; animal model; animal tissue; Article; cell transplantation; controlled study; drug effect; drug mechanism; drug screening; glucose blood level; glycemic control; hyperglycemia; insulin dependent diabetes mellitus; insulin release; male; mouse; nonhuman; pancreas islet; pancreas islet beta cell; priority journal; protein expression; vascularization; animal; blood; Diabetes Mellitus, Type 1; dose response; drug effects; metabolism; pancreas islet; treatment outcome; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mice; Streptozocin; Treatment Outcome; Tretinoin; Vascular Endothelial Growth Factor A
Publisher
Elsevier B.V.
Type
journal article