ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease
Journal
Cardiology
Journal Volume
107
Journal Issue
4
Pages
321-328
Date Issued
2007
Author(s)
Abstract
Background: TheI823M polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene has been reported to affect plasmahigh-density lipoprotein cholesterol (HDL-C) level. Information about its relationship to coronary artery disease (CAD) is limited. Methods and Results: We included 205 patients with angiographically documented CAD and 201 controls from the general population. We found thatI823M polymorphism was a significant source of variation of HDL-C (p = 0.024 after adjustment for age, sex, body mass index, smoking and alcohol drinking). Subjects with M823/M823 homozygotes (n = 103) had a higher HDL-C than those with I823/I823 or I823/M823 genotype (n = 98) (50.5 ± 9.7 vs. 47.6 ± 10.1 mg/dl, p = 0.039). I823M polymorphism was not a predictor of CAD in multivariate analysis (adjusted odds ratio = 1.5 [0.9-2.5], p = 0.145). However, it interacted with low HDL-C level to increase the risk of CAD. The odds ratio of CAD with M823 homozygosity was 5.3 (2.0-20.0) in patients with HDL-C ?35 mg/dl, but was only 1.0 (0.5-2.0) in those with HDL >40 mg/dl (p = 0.039 for interaction). Conclusions: M823 variant of the ABCA1 gene was associated with a higher HDL-C. Furthermore, I823M polymorphism interacted with low-HDL-C on the risk of CAD. It served as a marker to identify high-risk patients for CAD in subjects with low-HDL-C. Copyright ? 2007 S. Karger AG.
SDGs
Other Subjects
ABC transporter A1; high density lipoprotein cholesterol; low density lipoprotein cholesterol; adult; age distribution; article; body mass; cholesterol blood level; cholesterol metabolism; controlled study; coronary artery disease; coronary risk; disease association; drinking behavior; female; genetic association; genetic polymorphism; genetic risk; homozygosity; homozygote; human; major clinical study; male; multivariate analysis; prediction; priority journal; risk assessment; sex ratio; smoking; Aged; ATP-Binding Cassette Transporters; Case-Control Studies; Cholesterol, HDL; Coronary Angiography; Coronary Stenosis; Female; Genetic Markers; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide
Type
journal article