A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers
Journal
Journal of Materials Chemistry B
Journal Volume
6
Journal Issue
17
Pages
2536-2540
Date Issued
2018
Author(s)
Abstract
Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru-CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru-CO to form ruthenium oxide nanoparticles (RuO2 NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO2 NPs. A concentration as low as 17 ng mL-1 of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis. ? The Royal Society of Chemistry 2018.
SDGs
Other Subjects
Biosensors; Diagnosis; Diseases; Graphene; Adsorption properties; Biomedical fields; Cancer diagnosis; Decarbonylations; Matrix metalloproteinase-2; Quantitative detection; Ruthenium carbonyl; Vascular disease; Ruthenium compounds
Type
journal article