A Dual Selective Antitumor Agent and Fluorescence Probe: the Binary BMVC-Porphyrin Photosensitizer
Resource
ChemMedChem 3 (5): 725-728
Journal
ChemMedChem
Journal Volume
3
Journal Issue
5
Pages
725-728
Date Issued
2008
Date
2008
Author(s)
Abstract
(Chemical Equation Presented) Two in one: o-2P-B (shown) generates singlet oxygen for photoinduced cytotoxicity that is highly selective for cancer cells without damaging normal cells. The required excitation wavelength is very well suited for tissue penetration in photodynamic therapy (PDT). The excellent contrast in cellular imaging of o-2B-P can be applied to monitor the pathway of PDT and serve as a cell death marker. ? 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Subjects
Cell death markers; Cytotoxicity; FRET; Photoinduced translocation; Singlet oxygen
SDGs
Other Subjects
3,6 bis(1 methyl 4 vinylpyridium)carbazole diiodide; 3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; antineoplastic agent; carbazole derivative; fluorescent dye; photosensitizing agent; porphyrin; pyridinium derivative; article; chemistry; human; lung tumor; pathology; photochemotherapy; Antineoplastic Agents; Carbazoles; Fluorescent Dyes; Humans; Lung Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; Pyridinium Compounds
Type
journal article