New Cytotoxic Xenia Diterpenoids from the Formosan Soft Coral Xenia umbellata
Resource
Journal of Natural Products 65 (12): 1882-1885
Journal
Journal of Natural Products
Journal Volume
65
Journal Issue
12
Pages
1882-1885
Date Issued
2002
Date
2002
Author(s)
Abstract
Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
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Other Subjects
9 deoxy 7,8 epoxyxeniloide E; 9 deoxyxenialactol C; 9 deoxyxeniloide E; dichloromethane; diterpenoid; unclassified drug; xenibecin; xeniolide G; xeniolide H; xenitacin; article; cancer cell culture; carbon nuclear magnetic resonance; controlled study; drug cytotoxicity; drug isolation; human; human cell; in vitro study; nuclear Overhauser effect; proton nuclear magnetic resonance; stereochemistry; structure activity relation; Animals; Anthozoa; Antineoplastic Agents; Chromatography, Thin Layer; Colonic Neoplasms; Diterpenes; Drug Screening Assays, Antitumor; Leukemia P388; Lung Neoplasms; Mice; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa
Type
journal article
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