Sesquiterpenoids and Artificial 19-Oxygenated Steroids from the Formosan Soft Coral Nephthea erecta
Resource
Journal of Natural Products 70: 1449-1453
Journal
Journal of Natural Products
Journal Volume
70
Journal Issue
9
Pages
1449-1453
Date Issued
2007
Date
2007
Author(s)
Abstract
Chemical investigations on the acetone and MeOH solubles of the soft coral Nephthea erecta have afforded five new sesquiterpenoids (1-5), one known sesquiterpene, kelsoene (6), and two known 19-oxygenated steroids (10 and 11). In addition, three unexpected artificial 19-oxygenated steroids (7-9) were obtained by letting 10 and 11 stand in CDCl3 for prolonged periods of time. The structures of 1-9 were elucidated by extensive spectroscopic analyses, and their cytotoxicity against selected cancer cells was measured in vitro. ? 2007 American Chemical Society and American Society of Pharmacognosy.
Other Subjects
acetone; kelsoene; methanol; sesquiterpene; sesquiterpenoid; steroid; unclassified drug; article; cancer cell; controlled study; coral; cytotoxicity; drug isolation; human; human cell; in vitro study; nuclear magnetic resonance; spectroscopy; Animals; Anthozoa; Antineoplastic Agents; Drug Screening Assays, Antitumor; Molecular Structure; Sesquiterpenes; Steroids; Taiwan; Alcyonacea; Nephthea
Type
journal article
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