Neuronal circuitry for recognition memory of object and place in rodent models
Journal
Neuroscience & Biobehavioral Reviews
Series/Report No.
Neuroscience and Biobehavioral Reviews
Journal Volume
141
Start Page
104855
ISSN
0149-7634
Date Issued
2022-10
Author(s)
Abstract
Rats and mice are used for studying neuronal circuits underlying recognition memory due to their ability to spontaneously remember the occurrence of an object, its place and an association of the object and place in a particular environment. A joint employment of lesions, pharmacological interventions, optogenetics and chemogenetics is constantly expanding our knowledge of the neural basis for recognition memory of object, place, and their association. In this review, we summarize current studies on recognition memory in rodents with a focus on the novel object preference, novel location preference and object-in-place paradigms. The evidence suggests that the medial prefrontal cortex- and hippocampus-connected circuits contribute to recognition memory for object and place. Under certain conditions, the striatum, medial septum, amygdala, locus coeruleus and cerebellum are also involved. We propose that the neuronal circuitry for recognition memory of object and place is hierarchically connected and constructed by different cortical (perirhinal, entorhinal and retrosplenial cortices), thalamic (nucleus reuniens, mediodorsal and anterior thalamic nuclei) and primeval (hypothalamus and interpeduncular nucleus) modules interacting with the medial prefrontal cortex and hippocampus.
Subjects
Cell type specificity
Entorhinal cortex
Hippocampus
Medial prefrontal cortex
Object recognition
Spatial memory
Thalamus
Publisher
Elsevier BV
Type
journal article