Preparation of liposomal progesterone and its application on the measurement of progesterone interpreted via electrochemical and colorimetric sensing platforms
Journal
Electroanalysis
Journal Volume
25
Journal Issue
4
Pages
1017-1022
ISSN
1040-0397
Date Issued
2013-02-10
Author(s)
Abstract
We herein demonstrate a successful synthesis of methylene blue (MB)-encapsulated liposomal progesterone (LP) with an amplification merit beneficial for analytical applications. Both colormetric and electrochemical immunosensing strips for the leveling of progesterone, a hormone that helps to regulate the menstrual cycle of women, were achieved and characterized. Particular attention was given to the incorporation of an electrochemical screen-printed electrode toward disposable and deployed diagnostics, enabling the reliable quantification of progesterone in connection to a LOD of 0.83pg/mL. The novel, simple and specific amplification approach holds the promise to endorse a fast and high-fidelity diagnostics required for immediate therapeutic attempts.
Subjects
Bioelectroanalysis
Bioengineering
Immunosensor
Nanotechnology
SDGs
Publisher
Wiley-VCH Verlag
Type
journal article