Effect of saturated/unsaturated phosphatidylcholine ratio on the stability of liposome-encapsulated hemoglobin
Journal
International Journal of Pharmaceutics
Journal Volume
172
Journal Issue
1????
Pages
161-167
Date Issued
1998
Author(s)
DOI
0378-5173
Abstract
The influence of different combinations of saturated and unsaturated phosphatidylcholines (PCs) as well as addition of α-tocopherol on lipid peroxidation and particle size change was analyzed. Because unsaturated egg PC was susceptible to peroxidation, partially hydrogenated egg PC or hydrogenated egg PC (H-PC) was frequently used instead of egg PC. The efficacy of another alternative with combinations of saturated and unsaturated PCs was investigated. Oxidation can be inhibited by adding α-tocopherol in the lipid formulation or by using different combinations of H-PC and PC. Adding α-tocopherol was shown to cause physical instability of liposomes, and increase the possibility of aggregation. Increasing the H-PC content in the liposome formulation will effectively reduce the peroxidation. The stability of liposome was dependent on both α-tocopherol and H-PC to PC ratio. Encapsulating hemoglobin in the liposome would promote the lipid peroxidation. Copyright (C) 1998 Elsevier Science B.V.
Subjects
LEH; Liposome; Peroxidation
Other Subjects
alpha tocopherol; hemoglobin; liposome; phosphatidylcholine; article; biodegradation; encapsulation; lipid peroxidation; particle size; priority journal; storage
Publisher
journal article
Type
journal article