Targeting the cutaneous microbiota in atopic dermatitis: 'A new hope' or 'attack of the CoNS'?
Journal
Clinical and translational medicine
Journal Volume
12
Journal Issue
5
Date Issued
2022
Author(s)
Abstract
Although evidence showing that Staphylococcus aureus (S. aureus) is directly causative of atopic dermatitis (AD) is still lacking, there is evidence that S. aureus abundance is associated with disease flares and therapeutic responses. Patients receiving ATx201 OINTMENT 2% twice-daily had a significant reduction in the abundance of S. aureus and increasing Shannon diversity of skin microbiome compared to vehicle after seven days. A small molecule with a narrow-spectrum effect, especially on S. aureus, might be an attractive alternative for the treatment of AD.
Subjects
AD; Staphylococcus aureus; Staphylococcus epidermidis; biofilm; microbiome
Publisher
JOHN WILEY & SONS LTD
Type
journal article