From neuraminidase inhibitors to conjugates: A step towards better anti-influenza drugs?
Journal
Future Medicinal Chemistry
Journal Volume
6
Journal Issue
7
Pages
757-774
Date Issued
2014
Author(s)
Abstract
For the treatment of seasonal flu and possible pandemic infections the development of new anti-influenza drugs that have good bioavailability against a broad spectrum of influenza viruses including the resistant strains is needed. In this review, we summarize previous methods for the structural modification of zanamivir, a potent neuraminidase inhibitor that has rare drug resistance, in order to develop effective anti-influenza drugs. We also report recent research into the design of multivalent zanamivir drugs and bifunctional zanamivir conjugates, some of which have shown better efficacy in animal experiments. As a step towards developing improved antivirals, conjugating anti-influenza drugs with anti-inflammatory agents can improve oral bioavailability and also exert synergistic effect in influenza therapy. ? 2014 Future Science Ltd.
SDGs
Other Subjects
amantadine; anti influenza agent; antiinflammatory agent; antivirus agent; arbidol; influenza vaccine; laninamivir; laninamivir octanoate; oseltamivir; peramivir; protein M2; rimantadine; sialidase inhibitor; unclassified drug; zanamivir; antivirus agent; enzyme inhibitor; sialidase; zanamivir; antiviral resistance; conjugate; drug bioavailability; drug conjugation; drug efficacy; drug potentiation; genome analysis; human; influenza; Influenza virus; life cycle; medical research; nonhuman; photodynamic therapy; priority journal; review; vaccination; analogs and derivatives; animal; antagonists and inhibitors; chemistry; drug design; drug effects; enzymology; Influenza, Human; metabolism; molecularly targeted therapy; Orthomyxoviridae Infections; Orthomyxovirus; physiology; virology; Animals; Antiviral Agents; Drug Design; Enzyme Inhibitors; Humans; Influenza, Human; Molecular Targeted Therapy; Neuraminidase; Orthomyxoviridae; Orthomyxoviridae Infections; Zanamivir
Type
journal article