Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2005 update
Journal
Liver International
Journal Volume
25
Journal Issue
3
Pages
472-489
Date Issued
2005
Author(s)
Liaw Y.-F.
Leung N.
Guan R.
Lau G.K.K.
Merican I.
McCaughan G.
Gane E.
Omata M.
Chutaputti B.A.
Chien R.N.
Cooksley G.
Han K.H.
Ichida T.
Lai M.Y.
Lesmana L.
Piratvisuth T.
Sarin S.K.
Sollano J.
Suh D.J.
Yao G.B.
Yeh C.T.
Yokosuka O.
Abstract
Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update. Methods: New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL. Results: Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested. Conclusion: The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment. ? Blackwell Munksgaard 2005.
Subjects
Adefovir; Chronic hepatitis B; Hepatic decompensation; Interferon; Lamivudine; Liver transplantation
SDGs
Other Subjects
adefovir; adefovir dipivoxil; alanine aminotransferase; alpha interferon; clevudine; emtricitabine; entecavir; famciclovir; fialuridine; hepatitis B antibody; interleukin 12; lamivudine; lobucavir; peginterferon; peginterferon alpha2a; peginterferon alpha2b; ribavirin; telbivudine; tenofovir; thymosin; vidarabine; virus antigen; virus DNA; alanine aminotransferase blood level; antibiotic prophylaxis; antiviral activity; cancer chemotherapy; Chinese medicine; chronic hepatitis; clinical trial; comorbidity; depression; drug approval; drug dose regimen; drug efficacy; drug indication; drug mechanism; drug safety; drug substitution; fatigue; flu like syndrome; hepatitis B; Hepatitis B virus; hepatitis C; human; Human immunodeficiency virus infection; immunological tolerance; infection control; liver cirrhosis; liver transplantation; neutropenia; outcomes research; pathogenesis; patient care; patient monitoring; patient satisfaction; practice guideline; pregnancy; review; risk benefit analysis; thrombocytopenia; virus replication; Antiviral Agents; Asia; Australia; Hepatitis B, Chronic; Humans; New Zealand; Pacific Islands; Practice Guidelines
Type
review