Syngas reactions. XIV. Amidocarbonylation as a route to α-aminocarboxylix acids
Journal
Journal of Organometallic Chemistry
Journal Volume
417
Journal Issue
1-2
Pages
99-110
Date Issued
1991
Author(s)
Abstract
The amidocarbonylation of olefin and aldehyde substrates has been applied to the synthesis of a variety of amidocarboxylic acids, including surface active agents (e.g. C14C16 N-acyl-α-amino acids), specialty surfactants (such as the sarcosinates), intermediates for sweeteners (e.g. aspartame), food additives (e.g. glutamic acid), and certain chelating agents. Homogeneous cobalt and rhodium-based catalysts, modified, for example, with sulfoxide and bidentate phosphine ligands, have been tailored to the synthesis of each individual class of product. Process studies, including examinations of reaction rate, product selectivity, as well as catalyst stability, have been undertaken for N-acetylglycine and amino acid surfactant syntheses. © 1991.
Type
journal article