The CAM Model—Q&A with Experts
Journal
Cancers
Journal Volume
15
Journal Issue
1
Date Issued
2023-01-01
Author(s)
Fischer, Dagmar
Fluegen, Georg
Garcia, Paul
Ghaffari-Tabrizi-Wizsy, Nassim
Gribaldo, Laura
Rasche, Volker
Ribatti, Domenico
Rousset, Xavier
Pinto, Marta Texeira
Viallet, Jean
Wang, Yan
Schneider-Stock, Regine
Abstract
The chick chorioallantoic membrane (CAM), as an extraembryonic tissue layer generated by the fusion of the chorion with the vascularized allantoic membrane, is easily accessible for manipulation. Indeed, grafting tumor cells on the CAM lets xenografts/ovografts develop in a few days for further investigations. Thus, the CAM model represents an alternative test system that is a simple, fast, and low-cost tool to study tumor growth, drug response, or angiogenesis in vivo. Recently, a new era for the CAM model in immune-oncology-based drug discovery has been opened up. Although there are many advantages offering extraordinary and unique applications in cancer research, it has also disadvantages and limitations. This review will discuss the pros and cons with experts in the field.
Subjects
angiogenesis model | drug discovery | immune-oncology | metastasis model | personalized therapy | standard operation procedures | tumor growth
SDGs
Type
review