Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole-body PET/MR: Correlation with pathological prognostic factors
Journal
Journal of Magnetic Resonance Imaging
Journal Volume
42
Journal Issue
6
Pages
1723-1732
Date Issued
2015
Abstract
Purpose To evaluate the correlation between maximum standardized uptake value (SUVmax) and minimum apparent diffusion coefficient (ADCmin) of endometrial cancer derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors. Materials and Methods This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive patients with endometrial cancer were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty-six patients with measurable tumors on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUVmax and ADCmin of the tumors. The Mann-Whitney U-test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors. Results The mean SUVmax and ADCmin were 14.7 ± 7.1 and 0.48 ± 0.13 × 10-3 mm2/s, respectively. A significant inverse correlation was found between SUVmax and ADCmin (r = -0.53; P = 0.001). SUVmax was significantly higher in tumors with advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05). ADCmin was lower in tumors with higher grade, advanced stage, and cervical invasion (P < 0.05). The ratio of SUVmax to ADCmin was higher in tumors with higher grade, advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05). Conclusion SUVmax and ADCmin of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors. ? 2015 Wiley Periodicals, Inc.
SDGs
Other Subjects
biological marker; fluorodeoxyglucose f 18; gadoterate meglumine; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; apparent diffusion coefficient; Article; cancer grading; cancer prognosis; cancer staging; clinical article; computer assisted emission tomography; contrast enhancement; controlled study; diagnostic accuracy; diffusion coefficient; disease association; endometrium cancer; female; human; image analysis; lymph node metastasis; priority journal; prospective study; radiological parameters; receiver operating characteristic; standardized uptake value; tumor volume; uterine cervix carcinoma; very elderly; whole body imaging; biological model; clinical trial; computer assisted diagnosis; computer simulation; diffusion weighted imaging; Endometrial Neoplasms; image enhancement; metabolic clearance rate; middle aged; multimodal imaging; positron emission tomography; prevalence; procedures; prognosis; reproducibility; risk factor; sensitivity and specificity; statistics; system analysis; Adult; Aged; Aged, 80 and over; Computer Simulation; Diffusion Magnetic Resonance Imaging; Endometrial Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Metabolic Clearance Rate; Middle Aged; Models, Biological; Multimodal Imaging; Positron-Emission Tomography; Prevalence; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Statistics as Topic; Systems Integration; Whole Body Imaging
Type
journal article