GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death

Brugada syndrome (BrS) is a rare inherited disease causing sudden cardiac death (SCD). Copy number variants (CNVs) can contribute to disease susceptibility, but their role in Brugada syndrome (BrS) is unknown. We aimed to identify a CNV associated with BrS and elucidated its clinical implications.

Subjects

Brugada syndrome; Genetics; Inherited cardiac arrhythmia; Sudden cardiac death