Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3
Journal
Annals of the rheumatic diseases
Journal Volume
70
Journal Issue
9
Pages
1655
Date Issued
2011-09
Author(s)
Chen, Yu-Hsuan
Chen, Wei-Yu
Wu, Po-Chang
Tsai, Chang-Youh
Abstract
The molecular basis for spontaneous resolution of acute gouty arthritis (GA) remains unclear. The hypothesis that extracellular and intracellular mechanisms play roles in resolving acute GA was tested.
Subjects
TUMOR-NECROSIS-FACTOR; MONOSODIUM URATE CRYSTALS; INDUCED ACUTE-INFLAMMATION; MONOHYDRATE CRYSTALS; IMMUNE-RESPONSES; GENE-EXPRESSION; SYNOVIAL-FLUID; IN-VITRO; MACROPHAGES; CRITERIA
Other Subjects
cytokine inducible SH2 containing protein; interleukin 1 receptor blocking agent; interleukin 10; messenger RNA; regulator protein; small interfering RNA; suppressor of cytokine signaling; suppressor of cytokine signaling 1; suppressor of cytokine signaling 2; suppressor of cytokine signaling 3; suppressor of cytokine signaling 4; suppressor of cytokine signaling 5; suppressor of cytokine signaling 6; suppressor of cytokine signaling 7; transforming growth factor beta1; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; unclassified drug; urate; acute disease; animal cell; article; cell stimulation; clinical article; controlled study; cytokine production; enzyme linked immunosorbent assay; gene silencing; gout; human; human cell; human tissue; immunoblotting; immunohistochemistry; macrophage; mononuclear cell; mouse; nonhuman; osteoarthritis; priority journal; promoter region; protein analysis; protein binding; protein expression; quantitative assay; reverse transcription polymerase chain reaction; synovial fluid level; synovium; upregulation; Acute Disease; Animals; Arthritis, Gouty; Cells, Cultured; Cytokines; Humans; Inflammation Mediators; Interleukin-10; Macrophages; Mice; Osteoarthritis, Knee; Receptors, Tumor Necrosis Factor; Remission, Spontaneous; Suppressor of Cytokine Signaling Proteins; Synovial Fluid; Synovial Membrane; Transforming Growth Factor beta1; Uric Acid
Publisher
B M J PUBLISHING GROUP
Type
journal article