NO ASSOCIATION BETWEEN GENETIC POLYMORPHISMS OF CYP1A1, GSTM1, GSTT 1, GSTP1, NAT2, AND NASOPHARYNGEAL CARCINOMA IN TAIWAN
Resource
CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION v.12 n.2 pp.179-180
Journal
CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION v.12 n.2 pp.179-180
Pages
-
Date Issued
2003
Date
2003
Author(s)
CHENG, YU-JUEN
HSU, MOW-MING
Abstract
NPC2 is rare in most populations around the world but common in southern China and Southeast Asia. Both genetic and environmental factors are purported to account for the development of NPC. Many Phase I and Phase II enzymes get involved in the metabolism of carcinogens. Some of these enzymes are polymorphic in genotypes that show considerable variation in their activities, which, in turn, determine individual susceptibility to cancer risk (1) . No studies to date have examined simultaneously the association between genetic polymorphisms of multiple xenobiotic-metabolizing enzymes and NPC. We have previously reported an association between genetic polymorphism in the CYP2E1 gene and risk of NPC (2) . In this study, we examine the association with NPC of genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, and NAT2.
Subjects
CANCER
RISK
IDENTIFICATION
SUSCEPTIBILITY
BLADDER
CYP2E1
SDGs
Type
journal article