The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase
Journal
Journal of Biomedical Science
Journal Volume
30
Journal Issue
1
Date Issued
2023-08-14
Author(s)
Yang, Yi-Chieh
Lin, Yung-Wei
Lee, Wei-Jiunn
Lai, Feng-Ru
Ho, Kuo-Hao
Chu, Chih-Ying
Chen, Ji-Qing
Tung, Min-Che
Hsiao, Michael
Wen, Yu-Ching
Chien, Ming-Hsien
Abstract
KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the role of KSRP in clear cell renal cell carcinoma (ccRCC) remains poorly understood.
Subjects
EMT; KSRP; NEDD4L; Progression; ccRCC
SDGs
Publisher
BioMed Central Ltd
Type
journal article