Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus
Journal
Virology journal
Journal Volume
19
Journal Issue
1
Date Issued
2022-10-17
Author(s)
Chiou, Wei-Chung
Lu, Hsu-Feng
Chen, Jui-Chieh
Lai, Yu-Heng
Huang, Yuan-Li
Tien, Ni
Huang, Cheng
Abstract
Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis. Chronic hepatitis D, resulting from HBV/HDV coinfection, is considered to be the most severe form of viral hepatitis and affects 12-20 million people worldwide. Involved in the endocytosis and exocytosis of cellular and viral proteins, clathrin contributes to the pathogenesis and morphogenesis of HDV. Previously, we demonstrated that HDV-I and -II large hepatitis delta antigens (HDAg-L) possess a putative clathrin box that interacts with clathrin heavy chain (CHC) and supports HDV assembly.
Subjects
Clathrin box; Clathrin heavy chain; HDV genotypes; Hepatitis delta antigen; W box
SDGs
Publisher
BMC
Type
journal article