環境職業生殖危害(三)-台灣地區男性氯乙烯聚合工人配偶受孕所需時間及其下一代出生異常之研究(2/2)
Other Title
Environmental and occupational reproductive hazards (3) -
Time-to-pregnancy among the wives and adverse birth outcomes
among the offspring of male polyvinyl chloride workers in Taiwan
(2/2)
Time-to-pregnancy among the wives and adverse birth outcomes
among the offspring of male polyvinyl chloride workers in Taiwan
(2/2)
Date Issued
2002-07-31
Date
2002-07-31
Author(s)
陳保中
DOI
902320B002124
Abstract
Although there were several published works on
abnormal liver functions, liver cirrhosis or cancer, and
genetic damages of Taiwan polyvinyl chloride (PVC)
cohort, the potential effect of vinyl chloride monomer
(VCM) exposure on reproduction has not yet been
studied. Male VCM-exposed workers have been
reported loss of libido and reduced spermatogenesis
but the effect of male VCM exposure on next
generation was inconclusive. Now it is a chance to
investigate the effect of male VCM exposure on
fecundability measured by time to pregnancy and
adverse birth outcomes in Taiwan PVC cohort. This
study includes two sub-studies: time-to- pregnancy and
adverse birth outcome. The time-to-pregnancy
sub-study is designed as a retrospective cohort study to
investigate fecundability measured by waiting time to
pregnancy and pregnancy outcomes such as
spontaneous abortion and stillbirth among the wives of
male PVC workers. We recruited 416 valid male
workers that married within recent 15 years according
to Taiwan marriage registration database. In the first
year of this study, 93 wives of male PVC workers
participated and finished a face-to-face questionnaire
interview. The current analysis consisted of 210 valid
pregnancies only. In the preliminary analysis, we
found that relative fecundability ratio of the high
exposed group (more than 5 ppm) was less than that of
non-exposed group although it is not statistically
significant. The adverse birth outcome sub-study is
designed as a retrospective cohort study to investigate
adverse birth outcomes such as low birth weight,
prematurity, and infant death with congenital
anomalies among the offspring of male PVC workers.
We utilized 3925 male PVC workers that have valid
national identification numbers to link Taiwan birth
registration database during 1978-97. A total of 4,706
livebirths was identified to assess adverse birth
outcomes among the offspring of male polyvinyl
chloride workers. There were nine newborn deaths and
14 infant deaths among exposed group with unknown
exposure level but no case was found in the
non-exposed group. However, we could not analyze
them further due to few infant deaths. Among 648
births with known exposure level, there was no significant difference among different exposure groups,
either by exposure levels or duration of employment.
Subjects
vinyl chloride monomer
cohort studies
time to pregnancy
infant death
low birth weight
preterm birth
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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