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  4. Unveiling the enigma of acute kidney disease: predicting prognosis, exploring interventions, and embracing a multidisciplinary approach.
 
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Unveiling the enigma of acute kidney disease: predicting prognosis, exploring interventions, and embracing a multidisciplinary approach.

Journal
Kidney research and clinical practice
Journal Volume
43
Journal Issue
4
Start Page
406
End Page
416
ISSN
2211-9132
Date Issued
2024-07
Author(s)
SZU-YU PAN  
TAO-MIN HUANG  
Jiang, Zheng-Hong
Lin, Li-Chun
I-JUNG TSAI  
Wu, Tsung-Lin
Hsu, Chih-Yi
Wang, Ting
Chen, Hui-Chuen
YU-FENG LIN  
VIN-CENT WU  orcid-logo
DOI
10.23876/j.krcp.23.289
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/720807
Abstract
Acute kidney disease (AKD) is a critical transitional period between acute kidney injury and chronic kidney disease. The incidence of AKD following acute kidney injury is approximately 33.6%, and it can occur without identifiable preceding acute kidney injury. The development of AKD is associated with increased risks of chronic kidney disease, dialysis, and mortality. Biomarkers and subphenotypes are promising tools to predict prognosis in AKD. The complex clinical situations in patients with AKD necessitate a comprehensive and structured approach, termed "KAMPS" (kidney function check, advocacy, medications, pressure, sick day protocols). We introduce "MAND-MASS," an acronym devised to summarize the reconciliation of medications during episodes of acute illness, as a critical component of the sick day protocols at AKD. A multidisciplinary team care, consisting of nephrologists, pharmacists, dietitians, health educators, and nurses, is an optimal model to achieve the care bundle in KAMPS. Although the evidence for patients with AKD is still lacking, several potential pharmacological agents may improve outcomes, including but not limited to angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 inhibitors, and glucagon-like peptide 1 receptor agonists. In conclusion, accurate prognosis prediction and effective treatment for AKD are critical yet unmet clinical needs. Future studies are urgently needed to improve patient care in this complex and rapidly evolving field.
Subjects
Acute kidney injury
Drug therapy
Patient care team
Prognosis
Type
journal article

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