The Role of Race and Ethnicity in Chronic Rhinosinusitis With Nasal Polyps: A Scoping Review.
Journal
American journal of rhinology & allergy
Journal Volume
40
Journal Issue
1
Start Page
81
End Page
90
ISSN
1945-8932
Date Issued
2026-01
Author(s)
Wu, Arthur W
Thapa, Mishek
Alghezi, Mahdi
Oh, Eugene
Perez, Hector A
Tang, Dennis M
Jafari, Aria
Abuzeid, Waleed M
Abstract
BackgroundRace or ethnicity may influence chronic rhinosinusitis (CRS) endotype. Asian patients with CRS with nasal polyps (CRSwNP) may have increased Th1/Th17/mixed endotypes. However, there is a paucity of research concerning the endotype of non-Caucasian and non-Asian patients.ObjectiveThis review seeks to summarize literature as it pertains to associations between race or ethnicity and endotype with the goal highlighting knowledge gaps to guide future inquiry.MethodsSystematic scoping review methodology was used to summarize the current literature in accordance with PRISMA guidelines.ResultsOf the 8877 articles identified, 261 articles pertaining to race or ethnicity and endotype in CRSwNP were included. 163 studies with race or ethnicity-specific data involved Asian patients and demonstrated increased presence of Th1, Th17, and mixed endotypes, but also increasing prevalence of Th2 endotypes in multiple countries across Asia. There were 56 studies involving Caucasian patients demonstrating a predominance of Th2 endotypes though several recent studies also demonstrated that mixed inflammation may contribute to disease. There was a relative lack of literature involving other races and ethnicities, specifically: South Asian ( = 2), Middle Eastern ( = 9), African/African-American ( = 16), and Latino/Hispanic-American ( = 9). Allergic fungal rhinosinusitis appeared relatively prevalent in South Asian, Middle Eastern and African/African-American patients, though, relatively low numbers of studies and patients preclude definitive conclusions.ConclusionThis scoping review demonstrates that both race and ethnicity appear to play a role in affecting CRSwNP endotype. Additional research is necessary to investigate these factors, particularly in non-Caucasian and non-Asian patients.
Subjects
Asian people
Black or African Amerian
Hispanic or Latino
endotype
eosinophil
ethnicity
nasal polyps
neutrophil
race
rhinosinusitis
sinusitis
Type
review article