Composite Scores of Plasma Tau and β-Amyloids Correlate with Dementia in down Syndrome
Journal
ACS Chemical Neuroscience
Journal Volume
11
Journal Issue
2
Pages
191-196
Date Issued
2020
Author(s)
Fang W.-Q.
Yang S.-Y.
Chieh J.-J.
Chang L.-M.
Huang A.-C.
Abstract
Dementia frequently occurs in Down syndrome (DS) patients, and early intervention is important in its management. We have previously demonstrated a positive correlation of plasma β-amyloid Aβ42 levels and negative correlations of Aβ40 and tau levels with dementia in DS. In this study, we examined more cases and constructed composite scores with both tau and amyloids to correlate with dementia in DS. Plasma Aβ42, Aβ40, and tau proteins were measured by an immunomagnetic reduction assay in DS patients. Data were randomly and repeatedly split into training and validating sets, and logistic regression was applied to calculate the area under the curve (AUC) for each biomarker. A total of 73 DS patients (among them, 23 had neurodegeneration) and 77 controls were recruited. In DS patients without dementia, plasma Aβ40 and tau levels were highly elevated, but Aβ42 levels were lower than those of the healthy controls. DS patients with dementia, compared with DS patients with no dementia, had a large decline in Aβ40 and tau but a rise in Aβ42. For biomarker scores correlating with dementia, Aβ40 revealed an AUC of 0.912; the composite score of Aβ40 × tau revealed an AUC of 0.953; and a combined composite score of 0.1 for Aβ40 × Tau +0.9 Tau × Aβ40/Aβ42 achieved the highest AUC of 0.965. Therefore, composite biomarker scores including both plasma tau and β-amyloid levels correlate with dementia in DS better than using individual biomarker scores. The pattern of tau decline and Aβ42 rise in DS patients with dementia are also different from previous findings in Alzheimer's disease. ? 2019 American Chemical Society.
SDGs
Other Subjects
amyloid beta protein[1-40]; amyloid beta protein[1-42]; tau protein; amyloid beta protein; biological marker; MAPT protein, human; tau protein; adaptive behavior dementia questionnaire; adult; age; Article; behavioral and psychological symptoms of dementia; Clinical Dementia Rating; clinical feature; cognitive defect; comparative study; controlled study; cross-sectional study; dementia; dementia assessment; Down syndrome; female; human; major clinical study; male; priority journal; Youden index; blood; complication; dementia; Down syndrome; middle aged; Adult; Amyloid beta-Peptides; Biomarkers; Dementia; Down Syndrome; Female; Humans; Male; Middle Aged; tau Proteins
Publisher
American Chemical Society
Type
journal article