Pan-Drug-Resistant Pseudomonas Aeruginosa Causing Nosocomial Infection at a University Hospital in Taiwan
Resource
CLINICAL MICROBIOLOGY & INFECTION v.11 n.8 pp.670-673
Journal
CLINICAL MICROBIOLOGY & INFECTION
Journal Volume
v.11
Journal Issue
n.8
Pages
670-673
Date Issued
2005
Date
2005
Author(s)
HO, SHEN-WU
TENG, LEE-JENE
HSUEH, PO-REN
Abstract
This study evaluated the clinical and microbiological characteristics of 16 patients who were colonised or infected with 26 isolates of pan-drug- resistant Pseudomonas aeruginosa (PDRPA; intermediately-resistant or resistant to all cephalosporins, piperacillin–tazobactam, aztreonam, carbapenems, ciprofloxacin and aminoglycosides) in a university hospital during 1999–2002. All the isolates had colistin MICs ≤ 4 mg/L, 19 ( 73%) isolates had blaVIM-3 , and 25 (96%) isolates had class I integrons ( intI). Time- kill studies for two PDRPA blood isolates demonstrated synergism for cefepime–amikacin after 24 h. Pulsed-field gel electrophoresis analysis of the isolates revealed a polyclonal nature (12 pulsotypes), although clonal dissemination of PDRPA isolates among these patients was also present.
Subjects
Colistin
pan-drug resistance
Pseudomonas aeruginosa
synergism
time-kill studies